How Does Nexavar Work? part three

The First and Only Treatment Proven to Significantly Improve Overall Survival in Patients with Unresectable Hepatocellular Carcinoma (HCC)

to read our review about it here

to read How Does Nexavar Work? part one

to read How Does Nexavar Work? part two


How Does Nexavar Work? part three

ANGIOGENESIS
Nexavar inhibit angiogenesis so decrease blood supply to tumor

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How Does Nexavar Work? part two

The First and Only Treatment Proven to Significantly Improve Overall Survival in Patients with Unresectable Hepatocellular Carcinoma (HCC)

to read our review about it here

to read How Does Nexavar Work? part one

How Does Nexavar Work? part two

Deregulation in the pathways 1
A common feature of cancer cells is deregulation in the signaling pathways . while normal cells are highly controlled , cancer cells continously transmit messages for cellular proliferation



Deregulation in the pathways 2
nexavar block the above pathway

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How Does Nexavar Work? part one

The First and Only Treatment Proven to Significantly Improve Overall Survival in Patients with Unresectable Hepatocellular Carcinoma (HCC)

to read our review about it here

How Does Nexavar Work? part one

signaling pathways 1

Nexavar works along multiple signaling pathways to block cell proliferation and tumor angiogenesis.Nexavar blocks the receptor tyrosine kinases VEGFR (Vascular Endothelial Growth Factor Receptor) and PDGFR (Platelet Derived Growth Factor Receptor) and the RAF serine/threonine kinases along the RAF/MEK/ERK pathway

signaling pathways 2

signal from outside and inside the cells are sent to the nucleus in a process called signal transduction

nexavar inhibit this process

signaling pathways 3

the RAS protein is a key component of several signal transduction pathways invloved in cellular death .RAS like a switch that transmits external signal by a pathway called MAP kinase pathway

signaling pathways 4

the MAP kinase pathway consists of three kinases transmit signals

Written by
DR/ Hytham Hassan

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Nexavar - recent TREATMENT OF hepatocellular carcinoma -

Nexavar
- recent TREATMENT OF hepatocellular carcinoma -

Recent treatment become available in world for treatment of hcc and renal carcinoma
it is also oral treatment , this ttt will give more hope to hcc and renal carcinoma patient
it is Nexavar



Nexavar is an oral multiple kinase inhibitor for the treatment of patients with unresectable hepatocellular carcinoma (HCC), the most common form of liver cancer, and patients with advanced renal cell carcinoma (RCC), the most common type of kidney cancer.

How Does Nexavar Work?

Nexavar is designed to interfere with 2 signaling processes on cancer cells and tumor blood vessels.


By slowing tumor growth and reducing the blood supply of the tumor, Nexavar may prevent the growth and spread of cancer. These processes can also be important to normal cells, so targeted therapies like Nexavar may affect some normal cells as well.

what is the effect of Nexavar on the survival of hccpatient ?

What are the Possible Side Effects of Nexavar?

Nexavar may cause serious side effects, including

• Decreased blood flow to the heart and heart attack. Get emergency help right away and call your doctor if you get symptoms such as chest pain, shortness of breath, feel light-headed or faint, nausea, vomiting, or sweating a lot
• Bleeding problems. Nexavar may increase your chance of bleeding. Tell your doctor if you have any bleeding while taking Nexavar
• High blood pressure. Your blood pressure should be checked weekly during the first 6 weeks of starting Nexavar. Your high blood pressure should be checked regularly and any high blood pressure should be treated while you are taking Nexavar
• A skin problem called hand-foot skin reaction. This causes redness, pain, swelling, or blisters on the palms of your hands or soles of your feet. If you get this side effect, your doctor may change your dose or stop treatment for some time
• Perforation of the bowel. Tell your doctor right away if you get high fever, nausea, vomiting, or severe abdominal pain
• Possible wound healing problems. If you need to have a surgical or dental procedure, tell your doctor that you are taking Nexavar. Nexavar may need to be stopped until your wound heals after some types of surgery
• Birth defects or death of an unborn baby

Other side effects with Nexavar may include

• Rash, redness, itching or peeling of your skin
• Hair thinning or patchy hair loss
• Diarrhea (frequent and/or loose bowel movements)
• Nausea or vomiting
• Mouth sores
• Weakness
• Loss of appetite
• Numbness, tingling, or pain in your hands and feet
• Abdominal pain
• Tiredness
• Weight loss

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Cirrhosis : THE DIET SYSTEM

Cirrhosis : THE DIET SYSTEM

Cirrhosis one of the most common disease among the world population
Our trip in this disease is concerned about what the patient should do and should not do, how his life-style should be changed
Let us know first what he should avoid to limit cirrhosis progression and for better life

What to avoid

1-Alcohol must be completely avoided as alcohol itself cause cirrhosis in the healthy liver so it will destroy liver with cirrhosis very rapidly

2-Fat : we should restrict it but not to avoided completely

Why?

Restrict it as high fat diet may cause digestive problem as flatulence and offensive bulky stool so it is better to avoid animal fat

But not to completely avoided as body still need fat to remain healthy, this fat should be in the form of olive oil (the best), plant oil, fish oil, nuts , Omega-3 fatty acids, found in food such as salmon, walnuts, and flaxseed oil.

3-Salt intake should be decreased to about 1-2 gm daily and avoided in case of ascites as salt aggravate the accumulation of fluid in the form of ascites …….. But there is great problem counter the patient is that many food contain salts so we as doctors should give good flashlight in this problem ….. patient before buying canned food should read its composition as it may contain salts , Avoid fast food and packaged foods. , avoid monosodium glutamate (MSG, common in Chinese food) . canned soups

We will explain later how to replace the salt

4-Colored foods ( I mean foods with artificial colors ) should be avoided as we don’t want liver tired in the destruction of the artificial colors

5-Protein is necessary in repairing and maintaining your body tissue, especially your liver! Avoid meat protein but you can eat the chicken protein , but notice remove skin of chicken before cooking Plant protein is better as nuts, seeds, yogurt

6-Avoid usage of drugs without doctor consultation


Now let us know the good food

• Potassium salt can replace the normal table sodium salt
• The white portion of boiled egg
• Daily glass of skimmed milk
• Organic fruit, vegetables
• Plant protein nuts, seeds, yogurt
• olive oil (the best), plant oil, fish oil, nuts , Omega-3 fatty acids, found in food such as salmon,walnuts, and flaxseed oil
• Honey as it raise immunity very good

Written by
DR/ Hytham Hassan

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